Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.

Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: DDX3X All Species: 16.97
Human Site: S23 Identified Species: 26.67
UniProt: O00571 Number Species: 14
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O00571 NP_001347.3 662 73243 S23 F A G L D L N S S D N Q S G G
Chimpanzee Pan troglodytes Q6GVM6 660 73172 L21 Q Q L A N L D L N S E K Q S G
Rhesus Macaque Macaca mulatta XP_001095294 910 100218 S273 F A G L D L N S S D N Q S G G
Dog Lupus familis XP_861268 662 73195 S23 F A G L D L N S S D N Q S G G
Cat Felis silvestris
Mouse Mus musculus Q62167 662 73083 S23 F A G L D L N S S D N Q S G G
Rat Rattus norvegicus NP_001102328 659 72976 L21 Q Q L A G L D L T S P D S Q S
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001512924 651 71975 G17 S S D N Q S G G S T A S K G R
Chicken Gallus gallus NP_001025971 651 72031 L21 Q Q F S G L D L N S S D S Q S
Frog Xenopus laevis P24346 697 77284 I64 G R G G N G Y I N G M Q D D R
Zebra Danio Brachydanio rerio NP_571016 688 75828 G51 A A K N D A P G G W D N G R S
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9VHP0 798 85063 Y138 G G R F E D N Y N G G E F D S
Honey Bee Apis mellifera XP_391829 701 78642 G66 P Y S D R D R G R D R D R E R
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9M2F9 646 69224 S17 S E S E R A P S G G G W G Y S
Baker's Yeast Sacchar. cerevisiae P24784 617 67899 S12 P Q K V S N L S I N N K E N G
Red Bread Mold Neurospora crassa Q9P6U9 688 72037 P37 M R R S Y I P P H L R G K M G
Conservation
Percent
Protein Identity: 100 91.3 70.1 99.8 N.A. 98.6 95.3 N.A. 95.9 91.2 82.2 76.3 N.A. 51.7 58 N.A. N.A.
Protein Similarity: 100 95.3 70.3 99.8 N.A. 99 97.1 N.A. 97.2 94.7 88 83.8 N.A. 63.4 70 N.A. N.A.
P-Site Identity: 100 13.3 100 100 N.A. 100 13.3 N.A. 13.3 13.3 13.3 13.3 N.A. 6.6 6.6 N.A. N.A.
P-Site Similarity: 100 40 100 100 N.A. 100 26.6 N.A. 20 33.3 26.6 20 N.A. 26.6 6.6 N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. 49.5 49.4 52
Protein Similarity: N.A. N.A. N.A. 64.6 65.2 64.8
P-Site Identity: N.A. N.A. N.A. 6.6 20 6.6
P-Site Similarity: N.A. N.A. N.A. 6.6 40 13.3
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 7 34 0 14 0 14 0 0 0 0 7 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 7 7 34 14 20 0 0 34 7 20 7 14 0 % D
% Glu: 0 7 0 7 7 0 0 0 0 0 7 7 7 7 0 % E
% Phe: 27 0 7 7 0 0 0 0 0 0 0 0 7 0 0 % F
% Gly: 14 7 34 7 14 7 7 20 14 20 14 7 14 34 47 % G
% His: 0 0 0 0 0 0 0 0 7 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 7 0 7 7 0 0 0 0 0 0 % I
% Lys: 0 0 14 0 0 0 0 0 0 0 0 14 14 0 0 % K
% Leu: 0 0 14 27 0 47 7 20 0 7 0 0 0 0 0 % L
% Met: 7 0 0 0 0 0 0 0 0 0 7 0 0 7 0 % M
% Asn: 0 0 0 14 14 7 34 0 27 7 34 7 0 7 0 % N
% Pro: 14 0 0 0 0 0 20 7 0 0 7 0 0 0 0 % P
% Gln: 20 27 0 0 7 0 0 0 0 0 0 34 7 14 0 % Q
% Arg: 0 14 14 0 14 0 7 0 7 0 14 0 7 7 20 % R
% Ser: 14 7 14 14 7 7 0 40 34 20 7 7 40 7 34 % S
% Thr: 0 0 0 0 0 0 0 0 7 7 0 0 0 0 0 % T
% Val: 0 0 0 7 0 0 0 0 0 0 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 7 0 7 0 0 0 % W
% Tyr: 0 7 0 0 7 0 7 7 0 0 0 0 0 7 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _